Title : Assessment of depression among patients using drug resistant-tuberculosis treatment

Introduction: This study addresses the high prevalence of depression among patients undergoing treatment for drug-resistant tuberculosis (DR-TB) in Khyber Pakhtunkhwa, Pakistan. Depression is particularly challenging during the intensive phase of treatment, characterized by prolonged drug regimens, severe side effects, and social isolation. These factors complicate treatment adherence and outcomes, highlighting the need for integrated mental health support within DR-TB care frameworks.  

Methodology: Using a cohort-sequential design, 300 DR-TB patients were assessed for depression severity at various treatment stages via the Patient Health Questionnaire-9 (PHQ9). Additional demographic, socioeconomic, and clinical data were collected to evaluate factors associated with depression.  

Results: Findings indicate a 68% prevalence of depression among DR-TB patients, with younger patients, females, low-income individuals, and those lacking family support exhibiting higher depression levels. Depression severity peaked during the intensive treatment phase, where side effects and isolation exacerbated psychological stress. Depression was found to significantly reduce treatment adherence, increasing the likelihood of treatment failure by 3.5 times in severe cases. Integrated psychiatric interventions, including antidepressants and counseling, were associated with improved adherence and outcomes.

Conclusion: This study underscores the critical need to incorporate mental health services within DR-TB treatment programs. Providing early screening, tailored mental health interventions, and addressing socioeconomic barriers may enhance treatment adherence and reduce the risk of failure.

To be updated shortly..